Student-centred learning with near-peer tutoring compared with a standard faculty-led course for undergraduate training in abdominal ultrasound (the SIGNATURE trial). A multicentre open-label randomized controlled trial

Research question

We compare a new 21-hour blended-learning ultrasound course (5 hours of e-learning and 16 hours of near-peer tutoring) with the existing 21-hour faculty-led basic ultrasound course (“Grundkurs Abdomen”). Primary outcome measurement is students’ ultrasound skills measured by a six-station OSCE six months after the end of courses.

Secondary outcome measures: students’ ultrasound skills immediately after the courses and other measurement to better understand how to achieve effective student-centred learning supported by near-peer tutoring.

Statistical analysis plan

The statistical workup and the complete description of the used models can be found in this document.


Project leader Dr. med. Roman Hari
Project team

Michael Harris, Andi Limacher, Robin Walter, Kaspar Kälin, Christoph Berendonk, Tanja Birrenbach, Raphael Bonvin, Mathieu Nendaz, Andreas Serra

 Doctoral student
Robin Walter
 Funder SGAIM Foundation
Study design

The SIGNATURE trial is a multicentre, open-label randomized controlled non-inferiority trial with two parallel arms

Study start
September 2019