STatin discontinuation as pRevention among the Elderly And Multimorbid – a randomized non-inferiority clinical trial

Research question

Statins are among the most widely used drugs. While they were found to be effective for primary and secondary prevention of CVD in middle-aged subjects, their benefits for primary prevention in older people (aged ≥70) without CVD are uncertain, particularly for those with multimorbidity. However, statin side effects and drug interactions are common in a multimorbid elderly population and can negatively impact quality of life and increase adverse drug reaction-related hospitalizations.

The aim of STREAM is to conduct a statin deprescribing randomized controlled trial (RCT) to provide guidance on the long-term benefits and risks for the ever-growing multimorbid elderly population.


Project leader Prof. Dr. med. Nicolas Rodondi
Principal invastigator team

Prof. Dr. med. Nicolas Rodondi (Inselspital)

Prof. Dr. med Philipp Schütz (Aarau)

Prof. Dr. med. Jürg Hans Beer (Baden)

PD Dr. med. Marie Méan (CHUV)

Prof. Dr. med. Luca Gabutti (Bellinzona)

PD Dr. med. Sebastian Carballo (Geneva, Internal medicine)

Prof. Dr. med. Dina Zekry (Geneva, Geriatrics)

Prof. Dr. med. Mirjam Christ-Crain and Prof. Dr. med. Stefano Bassetti (Basel)

Prof. Dr. med. Jacques Donzé (Neuchâtel)

Prof. Dr. med. Heike Bischoff-Ferrari (University Hospital Zurich)

Prof. Dr. med. Lars Huber (City Hospital Zürich)

Prof. Dr. med. Omar Kherad (Meyrin)


Participating core sites:

-       Department of General Internal Medicine, Inselspital, Bern University Hospital, Bern

-       Cantonal Hospital Aarau

-       Cantonal Hospital Baden

-       Centre Hospitalier Universitaire Vaudois (CHUV)

-       Ospedale Regionale di Bellinzone e Valli

-       Triemli Hospital, Zurich

-       Department of Internal Medicine, Geneva University Hospitals

-       Department of Geriatrics, Geneva University Hospitals

-       University Hospital of Basel

-       Hospital of Neuchâtel

-       City Hospital and University Hospital of Zurich

-       La Tour Hospital, Meyrin

Participating auxiliary sites:

-       Cantonal Hospital Olten, Acute Geriatric Medicine

-       Cantonal Hospital Olten, Internal Medicine

-       Hospital Emmental, Burgdorf, Medizinische Klinik

-       Regional Hospital Emmental, Langnau

-       Geriatric Clinic St. Gallen

-       Hôpital du Valais, Internal Medicine

Participating primary health care institutes:

-       Primary health care institute of Bern (BIHAM)

-       Primary health care institute of the University of Fribourg

-       Centre for primary health care of St. Gallen

-       Association for primary health care of Lucerne

-       Association for primary health care of Basel

-       Primary health care institute of the University Hospital of Geneva

-       Primary health care institute of the University Hospital of Lausanne

-       MediX Switzerland
Funder(s) The trial is funded by the Swiss National Science Foundation (SNSF).


Study design The study is a multicenter, randomized, non-inferiority trial open labelled, with blinded outcome adjudication.
Study start

November 2021

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